Mitochondrial Morphofunctional Alterations in Smooth Muscle Cells of Aorta in Rats
نویسندگان
چکیده
منابع مشابه
Mitochondrial Morphofunctional Alterations in Smooth Muscle Cells of Aorta in Rats
In an experimental model of atherogenesis induced by hyperfibrinogenemia (HF), the pharmacological response of vitamin E was studied in order to assess its antioxidant effect on the mitochondrial morphofunctional alterations in aortic smooth muscle cells. Three groups of male rats were used: (Ctr) control, (AI) atherogenesis induced for 120 days, and (AIE) atherogenesis induced for 120 days and...
متن کاملMitochondrial alterations and apoptosis in smooth muscle from aged rats.
We studied changes in mitochondrial morphology and function in the smooth muscle of rat colon. Under confocal microscopy, tissues loaded with potentiometric dye displayed rapid and spontaneous depolarization. Cyclosporin A (CsA), inhibitor of the permeability transition pore (PTP), caused an increase in mitochondrial membrane potential (DeltaPsim) in tissues from adult young animals. In aged ra...
متن کاملConnection of smooth muscle cells to elastic lamellae in aorta of spontaneously hypertensive rats.
We have recently demonstrated that in large arteries of spontaneously hypertensive rats (SHR), there is no increase of stiffness despite the increase in wall thickness, a sign of mechanical adaptation of the arterial wall to the higher level of stress. Because the dense plaques of smooth muscle are a major site of anchorage between the muscle cells and extracellular matrix, we determined by ele...
متن کاملMorphofunctional renal alterations in rats induced by intrauterine hyperglycemic environment
INTRODUCTION The renal development of rats begins in intrauterine life, finishing by 15 days after birth. Diabetes and other diseases during pregnancy can cause systemic changes in the offspring. We evaluated the structural and functional renal alterations of the offspring from diabetic mothers. MATERIAL AND METHODS Pregnant rats were separated and 1, 7, 30 and 90 days-old (DO) pups were divi...
متن کاملanalysis of alterations in morphologic characteristics of mesenchymal stem cells by mechanical stimulation during differentiation into smooth muscle cells
background: mesenchymal stem cells (mscs) can be expanded and differentiated into many mature cell types including smooth muscle cells (smcs). in addition to growth factor, cyclic stretch contributes to differentiation of stem cells. mechanical stimuli are critical to morphological changes, development, regeneration, differentiation and pathology of mesenchymal tissues. the aim of this study is...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ISRN Cardiology
سال: 2014
ISSN: 2090-5599
DOI: 10.1155/2014/739526